The Health Experiences Research Network (HERN), launched in 2014, is a partnership between faculty affiliated with University of Wisconsin-Madison, Johns Hopkins University, Oregon Health & Science University, the Veterans Administration, and Yale University. HERN is committed to implementing the Database of Individual Patient Experience (DIPEx) methodology in the United States so that each qualitative research study is conducted with rigor and its corresponding public-facing web-based “module” is interpretive, deeply descriptive, and holistic. Because dialogue, diverse viewpoints and collaborative inquiry are essential to these dimensions of quality in qualitative research, we are committed to using team-based approaches, and multidisciplinary collaborations in our DIPEx studies. To support the development of high-quality modules in the USA, we are committed to abiding by DIPEx International Guidelines (see summary below) and to the following “Principles of Practice”, appropriately adapted to the U.S. context. These principles of practice have been drafted by identified qualitative researchers at each of the Network institutions, who come together as the ‘Qualitative Research Subgroup.’ It was then approved by the HERN Steering Committee in July, 2017. Beginning in September 2018, we will welcome the energy, dedication and talent of additional researchers who wish to produce additional US-based DIPEx modules, and who are prepared to commit to the guidelines, practices and expectations for interactions with HERN specified in the attached document.